Why would someone diagnosed with premenstrual dysphoric disorder (PMDD) be prescribed paroxetine as part of their treatment, while someone with premenstrual syndrome (PMS) would not?

Paroxetine is a selective serotonin reuptake inhibitor (SSRI), which affects serotonin signaling and can reduce the more severe mood symptoms of PMDD. PMS symptoms are generally less severe and are often managed without an SSRI, so paroxetine is not typically needed to target neurotransmitters. This does not mean it is unsafe for anyone with PMS; treatment depends on symptom severity and a clinician’s assessment.

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