"Is it madness, Mr. Holmes? Is it something in the blood? Have you any similar case in your experience? For God's sake, give me some advice, for I am at my wit's end."The tone of this passage is ________________.

The speaker asks urgent questions and pleads, “For God’s sake, give me some advice,” adding that he is “at my wit’s end.” These words show worry and desperation, so the tone is anxious, not simply sad or angry.

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