Many different types of mutations can occur within the body. Cystic fibrosis is a genetic disorder that is caused by different mutations within the CFTR gene. One mutation in the CFTR gene that leads to cystic fibrosis causes translation to end earlier in the gene sequence. Which type of mutation causes this translation error that leads to cystic fibrosis?
A nonsense mutation changes a codon for an amino acid into a stop codon. This makes translation end early, producing a shortened CFTR protein that may not function properly. Therefore, the mutation described is a nonsense mutation.
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