Which expression is a difference of squares with a factor of 2x + 5?

A difference of squares follows the rule a² − b² = (a + b)(a − b). Here, 4x² − 25 = (2x)² − 5² = (2x + 5)(2x − 5), so it has the factor 2x + 5. The correct choice is D, 4x² − 25.

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