Parkinson’s disease is a brain disorder that may be caused by mutations in several genes that code for the production of alpha-synuclein. Individuals who have Parkinson’s disease exhibit symptoms such as uncontrollable tremors, difficulty walking, and loss of coordination. How might geneticists determine where the mutations that cause Parkinson’s disease are located?

Geneticists use gene mapping to locate a mutation on a chromosome and determine which region or gene is associated with a disease. Since the question asks where the Parkinson’s-causing mutations are located, gene mapping is the appropriate method. STR analysis and DNA fingerprinting are mainly used to compare DNA samples, while PCR makes copies of selected DNA regions.

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