Assume the volume of air inhaled and exhaled is 500 mL. Calculate the difference (in mL) between the amount of oxygen inhaled and the amount of oxygen exhaled.

Inhaled air contains about 20.95% oxygen, so 500 mL contains 0.2095 × 500 = 104.75 mL of oxygen. Exhaled air contains about 16.37% oxygen, so it contains 0.1637 × 500 = 81.85 mL. The difference is about 104.75 − 81.85 = 22.9 mL, so the correct choice is 22.85 mL of oxygen.

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