As the map indicates, trade goods flowed both ways during the Columbian Exchange.Which of the following things was usually exchanged in only one direction, negatively impacting Indigenous people but not many Europeans?

Diseases were usually exchanged in one direction: Europeans brought illnesses such as smallpox to the Americas, where Indigenous people had little immunity. These epidemics caused enormous loss of life, while diseases from the Americas had far less impact on Europeans. So the correct choice is diseases.

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